Tryptamine accumulation caused by deletion of MrMao-1 in Metarhizium genome significantly enhances insecticidal virulence.
Identifieur interne : 000010 ( Main/Exploration ); précédent : 000009; suivant : 000011Tryptamine accumulation caused by deletion of MrMao-1 in Metarhizium genome significantly enhances insecticidal virulence.
Auteurs : Xiwen Tong [République populaire de Chine] ; Yundan Wang [République populaire de Chine] ; Pengcheng Yang [République populaire de Chine] ; Chengshu Wang [République populaire de Chine] ; Le Kang [République populaire de Chine]Source :
- PLoS genetics [ 1553-7404 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Délétion de gène (MeSH), Espèces réactives de l'oxygène (métabolisme), Metarhizium (génétique), Metarhizium (pathogénicité), Monoamine oxidase (génétique), Protéines d'insecte (métabolisme), Protéines fongiques (génétique), Récepteurs à hydrocarbure aromatique (métabolisme), Sauterelles (microbiologie), Sauterelles (métabolisme), Tryptamines (métabolisme), Virulence (génétique).
- MESH :
- génétique : Metarhizium, Monoamine oxidase, Protéines fongiques, Virulence.
- microbiologie : Sauterelles.
- métabolisme : Espèces réactives de l'oxygène, Protéines d'insecte, Récepteurs à hydrocarbure aromatique, Sauterelles, Tryptamines.
- pathogénicité : Metarhizium.
- Animaux, Délétion de gène.
English descriptors
- KwdEn :
- Animals (MeSH), Fungal Proteins (genetics), Gene Deletion (MeSH), Grasshoppers (metabolism), Grasshoppers (microbiology), Insect Proteins (metabolism), Metarhizium (genetics), Metarhizium (pathogenicity), Monoamine Oxidase (genetics), Reactive Oxygen Species (metabolism), Receptors, Aryl Hydrocarbon (metabolism), Tryptamines (metabolism), Virulence (genetics).
- MESH :
- chemical , genetics : Fungal Proteins, Monoamine Oxidase.
- genetics : Metarhizium, Virulence.
- metabolism : Grasshoppers, Insect Proteins, Reactive Oxygen Species, Receptors, Aryl Hydrocarbon, Tryptamines.
- microbiology : Grasshoppers.
- pathogenicity : Metarhizium.
- Animals, Gene Deletion.
Abstract
Metarhizium is a group of insect-pathogenic fungi that can produce insecticidal metabolites, such as destruxins. Interestingly, the acridid-specific fungus Metarhizium acridum (MAC) can kill locusts faster than the generalist fungus Metarhizium robertsii (MAA) even without destruxin. However, the underlying mechanisms of different pathogenesis between host-generalist and host-specialist fungi remain unknown. This study compared transcriptomes and metabolite profiles to analyze the difference in responsiveness of locusts to MAA and MAC infections. Results confirmed that the detoxification and tryptamine catabolic pathways were significantly enriched in locusts after MAC infection compared with MAA infection and that high levels of tryptamine could kill locusts. Furthermore, tryptamine was found to be capable of activating the aryl hydrocarbon receptor of locusts (LmAhR) to produce damaging effects by inducing reactive oxygen species production and immune suppression. Therefore, reducing LmAhR expression by RNAi or inhibitor (SR1) attenuates the lethal effects of tryptamine on locusts. In addition, MAA, not MAC, possessed the monoamine oxidase (Mao) genes in tryptamine catabolism. Hence, deleting MrMao-1 could increase the virulence of generalist MAA on locusts and other insects. Therefore, our study provides a rather feasible way to design novel mycoinsecticides by deleting a gene instead of introducing any exogenous gene or domain.
DOI: 10.1371/journal.pgen.1008675
PubMed: 32271756
PubMed Central: PMC7173932
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(metabolism)</term><term>Metarhizium (genetics)</term><term>Metarhizium (pathogenicity)</term><term>Monoamine Oxidase (genetics)</term><term>Reactive Oxygen Species (metabolism)</term><term>Receptors, Aryl Hydrocarbon (metabolism)</term><term>Tryptamines (metabolism)</term><term>Virulence (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Délétion de gène (MeSH)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Metarhizium (génétique)</term><term>Metarhizium (pathogénicité)</term><term>Monoamine oxidase (génétique)</term><term>Protéines d'insecte (métabolisme)</term><term>Protéines fongiques (génétique)</term><term>Récepteurs à hydrocarbure aromatique (métabolisme)</term><term>Sauterelles (microbiologie)</term><term>Sauterelles (métabolisme)</term><term>Tryptamines (métabolisme)</term><term>Virulence (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fungal Proteins</term><term>Monoamine Oxidase</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Metarhizium</term><term>Virulence</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Metarhizium</term><term>Monoamine oxidase</term><term>Protéines fongiques</term><term>Virulence</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Grasshoppers</term><term>Insect Proteins</term><term>Reactive Oxygen Species</term><term>Receptors, Aryl Hydrocarbon</term><term>Tryptamines</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Sauterelles</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Grasshoppers</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term><term>Protéines d'insecte</term><term>Récepteurs à hydrocarbure aromatique</term><term>Sauterelles</term><term>Tryptamines</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Metarhizium</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Metarhizium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Deletion</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Délétion de gène</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Metarhizium is a group of insect-pathogenic fungi that can produce insecticidal metabolites, such as destruxins. Interestingly, the acridid-specific fungus Metarhizium acridum (MAC) can kill locusts faster than the generalist fungus Metarhizium robertsii (MAA) even without destruxin. However, the underlying mechanisms of different pathogenesis between host-generalist and host-specialist fungi remain unknown. This study compared transcriptomes and metabolite profiles to analyze the difference in responsiveness of locusts to MAA and MAC infections. Results confirmed that the detoxification and tryptamine catabolic pathways were significantly enriched in locusts after MAC infection compared with MAA infection and that high levels of tryptamine could kill locusts. Furthermore, tryptamine was found to be capable of activating the aryl hydrocarbon receptor of locusts (LmAhR) to produce damaging effects by inducing reactive oxygen species production and immune suppression. Therefore, reducing LmAhR expression by RNAi or inhibitor (SR1) attenuates the lethal effects of tryptamine on locusts. In addition, MAA, not MAC, possessed the monoamine oxidase (Mao) genes in tryptamine catabolism. Hence, deleting MrMao-1 could increase the virulence of generalist MAA on locusts and other insects. Therefore, our study provides a rather feasible way to design novel mycoinsecticides by deleting a gene instead of introducing any exogenous gene or domain.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32271756</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>03</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>03</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1553-7404</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>04</Month></PubDate></JournalIssue><Title>PLoS genetics</Title><ISOAbbreviation>PLoS Genet</ISOAbbreviation></Journal><ArticleTitle>Tryptamine accumulation caused by deletion of MrMao-1 in Metarhizium genome significantly enhances insecticidal virulence.</ArticleTitle><Pagination><MedlinePgn>e1008675</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pgen.1008675</ELocationID><Abstract><AbstractText>Metarhizium is a group of insect-pathogenic fungi that can produce insecticidal metabolites, such as destruxins. Interestingly, the acridid-specific fungus Metarhizium acridum (MAC) can kill locusts faster than the generalist fungus Metarhizium robertsii (MAA) even without destruxin. However, the underlying mechanisms of different pathogenesis between host-generalist and host-specialist fungi remain unknown. This study compared transcriptomes and metabolite profiles to analyze the difference in responsiveness of locusts to MAA and MAC infections. Results confirmed that the detoxification and tryptamine catabolic pathways were significantly enriched in locusts after MAC infection compared with MAA infection and that high levels of tryptamine could kill locusts. Furthermore, tryptamine was found to be capable of activating the aryl hydrocarbon receptor of locusts (LmAhR) to produce damaging effects by inducing reactive oxygen species production and immune suppression. Therefore, reducing LmAhR expression by RNAi or inhibitor (SR1) attenuates the lethal effects of tryptamine on locusts. In addition, MAA, not MAC, possessed the monoamine oxidase (Mao) genes in tryptamine catabolism. Hence, deleting MrMao-1 could increase the virulence of generalist MAA on locusts and other insects. Therefore, our study provides a rather feasible way to design novel mycoinsecticides by deleting a gene instead of introducing any exogenous gene or domain.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tong</LastName><ForeName>Xiwen</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yundan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Pengcheng</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0001-5496-8357</Identifier><AffiliationInfo><Affiliation>Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Chengshu</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0003-1477-1466</Identifier><AffiliationInfo><Affiliation>Key Laboratory of Insect Developmental and Evolutionary Biology, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Le</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0003-4262-2329</Identifier><AffiliationInfo><Affiliation>State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS Genet</MedlineTA><NlmUniqueID>101239074</NlmUniqueID><ISSNLinking>1553-7390</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal 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MajorTopicYN="N">Fungal Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017353" MajorTopicYN="N">Gene Deletion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006110" MajorTopicYN="N">Grasshoppers</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019476" MajorTopicYN="N">Insect Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052981" MajorTopicYN="N">Metarhizium</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008995" MajorTopicYN="N">Monoamine 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Kang</name><name sortKey="Tong, Xiwen" sort="Tong, Xiwen" uniqKey="Tong X" first="Xiwen" last="Tong">Xiwen Tong</name><name sortKey="Wang, Chengshu" sort="Wang, Chengshu" uniqKey="Wang C" first="Chengshu" last="Wang">Chengshu Wang</name><name sortKey="Wang, Yundan" sort="Wang, Yundan" uniqKey="Wang Y" first="Yundan" last="Wang">Yundan Wang</name><name sortKey="Yang, Pengcheng" sort="Yang, Pengcheng" uniqKey="Yang P" first="Pengcheng" last="Yang">Pengcheng Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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